Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system.  The vision pathway,  including the retina, optic nerve, optic chiasm, optic thalamus and optic radiation can be involved. The present study showed that visual evoked potentials (VEP) could diagnose earlier than the clinical symptoms of MS and was superior to the MRI for the fundation of  the lesions of visual pathway in MS. Pathological changes of the retina in MS patients could be diagnosed and evaluated combining with optical coherence tomography (OCT) and scanning laser polarization instrument (SLP). The improvement of VEP techniques will be helpful to the diagnosis and treatment of MS.  (Int Rev Ophthalmol, 2012, 36: 138-142)